POSTDOCTORAL RESEARCHER (PROTEIN ENGINEERING) – ID# 224800
Please apply directly on the RCUH website to be considered for the position.
POSTDOCTORAL RESEARCHER (PROTEIN ENGINEERING) – ID# 224800.
CLOSING DATE: November 28, 2024, or until filled. Applications received after this deadline may be considered only if the position is not filled or up to the date a selection has been approved by the RCUH (whichever comes first). INQUIRIES: Dr. Wei Wen Su [email protected].
Regular, Full-Time, RCUH Non-Civil Service position with the Department of Molecular Biosciences and Bioengineering (MBBE), Su laboratory, located on the University of Hawai‘i at Manoa (UHM) campus in Honolulu, Hawai‘i. Continuation of employment is dependent upon program/operational needs, satisfactory work performance, availability of funds, and compliance with applicable Federal/State laws.
MONTHLY SALARY RANGE: $4,888 - $5,250/Mon.
DUTIES: Designs and generates gene constructs, and carries out genetic transformation for expression, primarily in yeast and plant systems. Designs and engineers autoprocessing protein (AP) variants to enhance performance using synthetic biology, rational mutagenesis, and directed evolution approaches. Validates improved AP in plant using agroinfiltration. Designs and conducts genetic and biochemical tests to probe the interplay between AP expression and cellular metabolism. Engineers conditional degron to enhance induction reversibility. Utilizes AP and degron systems in metabolic engineering. Assists in supervising grad students, and in preparing manuscripts, reports, and research proposals. The Su laboratory in the Department of Molecular Biosciences and Bioengineering works on innovative research that combines rational and combinatorial protein engineering, with high-throughput screening, to develop next-generation autoprocessing protein and conditional degron systems. These cutting-edge molecular technologies propel synthetic biology, metabolic engineering, and trait engineering forward, unlocking significant applications in medicine, agriculture, and industrial biotechnology.
PRIMARY QUALIFICATIONS:
EDUCATION
PhD from an accredited college or university in Bioengineering, Biotechnology, Chemical Engineering, Biochemistry, Biophysics, Chemical Biology, Protein Chemistry, Molecular Biology, or a related STEM field. (PhD candidates may apply but must submit evidence of PhD completion upon hire).
EXPERIENCE
One to three (1-3) years of research experience in molecular biology, biochemistry, or protein chemistry. Experience may be obtained during PhD studies.
KNOWLEDGE
Strong knowledge in protein chemistry, protein engineering, along with a robust understanding of synthetic biology, biochemistry and molecular biology
ABILITIES & SKILLS
Expert ability and skills to design and create gene constructs. Strong ability to carry out genetic transformation. Strong ability in using bioinformatic tools for protein modeling and analysis. Strong analytical skills to hypothesize, design experiments, and interpret results.Strong ability in comprehending and analyzing relevant scientific literature. Strong ability to communicate in English. Post Offer/Employment Condition: Must be able to complete the UH Laboratory Safety training within one (1) month from date of hire. Must be able to complete the Office of Research Compliance (ORC) General Biosafety training within one (1) month from date of hire.
POLICY/REGULATORY REQUIREMENT
As a condition of employment, employee will be subject to all applicable RCUH policies, procedures, and trainings and, as applicable, subject to University of Hawai‘i's and/or business entity's policies, procedures, and trainings. Violation of RCUH's, UH's, or business entity's policies and/or procedures or applicable State or Federal laws and/or regulations may lead to disciplinary action (including, but not limited to possible termination of employment, personal fines, civil and/or criminal penalties, etc.).
SECONDARY QUALIFICATIONS:
Research experience in protein directed evolution, mutant library development, and library screening. Experience in ubiquitin research. Experience in synthetic biology research. Experience in metabolic engineering research. Experience in engineering yeast, mammalian, and/or plant systems. Experience in computational protein structure analysis. Experience in CRISPR-related techniques.
APPLICATION REQUIREMENTS: Please go to https://www.rcuh.com/work/careers/. You must submit the following documents online to be considered for the position: 1) cover letter (indicating how you satisfy the primary and some, if not all, secondary qualifications), 2) resume, 3) names and contact information for at least three professional references, 4) copy of degree(s)/transcript(s)/certificate(s). All online applications must be submitted/received by the closing date (11:59 P.M. Hawai‘i Standard Time/RCUH receipt time) as stated on the job posting. If you do not have access to our system and the closing date is imminent, you may send additional documents to [email protected]. If you have questions on the application process and/or need assistance, please call (808)956-7262 or (808)956-0872. Please visit https://www.rcuh.com/document-library/3-000/benefits/rcuh-benefits-at-a-glance/ for more information on RCUH’s Benefits for eligible employees.
RCUH’s mission is to support and enhance research, development and training in Hawai‘i, with a focus on the University ofHawai‘i.
RCUH is an equal opportunity employer and all qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, national origin, ancestry, age, disability, genetic information, pregnancy, marital status, reproductive health decision, citizenship, gender identity or expression, domestic or sexual violence victim status, military/veteran status, or other grounds protected under applicable federal and state laws, except as permitted by law.
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